2X09

Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine- configured castanospermine and an amino-australine analogue

Summary for 2X09

Entry DOI	10.2210/pdb2x09/pdb
Related	2VZO 2VZP 2VZQ 2VZR 2VZS 2VZT 2VZU 2VZV 2X05
Descriptor	EXO-BETA-D-GLUCOSAMINIDASE, AMINO-AUSTRALINE, CADMIUM ION, ... (4 entities in total)
Functional Keywords	exo-beta-d-glucosaminidase, glycoside hydrolase, gh2, csxa, hydrolase, glycosidase
Biological source	AMYCOLATOPSIS ORIENTALIS
Cellular location	Secreted, extracellular space: Q56F26
Total number of polymer chains	2
Total formula weight	221981.28
Authors	Pluvinage, B.,Ghinet, M.G.,Brzezinski, R.,Boraston, A.B.,Stubbs, K.A. (deposition date: 2009-12-07, release date: 2010-02-09, Last modification date: 2023-12-20)
Primary citation	Pluvinage, B.,Ghinet, M.G.,Brzezinski, R.,Boraston, A.B.,Stubbs, K.A. Inhibition of the Exo-Beta-D-Glucosaminidase Csxa by a Glucosamine-Configured Castanospermine and an Amino-Australine Analogue. Org.Biomol.Chem., 7:4169-, 2009 Cited by PubMed Abstract: The synthesis of amino-derivatives of castanospermine and australine and their characterisation as inhibitors of the exo-beta-D-glucosaminidase CsxA through enzyme kinetics and X-ray structural analysis is described. PubMed: 19795054 DOI: 10.1039/B913235J PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation