2X05

Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine- configured castanospermine and an amino-australine analogue

2X05 の概要

• エントリーDOI: 10.2210/pdb2x05/pdb
• 関連するPDBエントリー: 2VZO 2VZP 2VZQ 2VZR 2VZS 2VZT 2VZU 2VZV
• 分子名称: EXO-BETA-D-GLUCOSAMINIDASE, AMINO-CASTANOSPERMINE, CADMIUM ION, ... (4 entities in total)
• 機能のキーワード: exo-beta-d-glucosaminidase, glycoside hydrolase, gh2, csxa, hydrolase, glycosidase
• 由来する生物種: AMYCOLATOPSIS ORIENTALIS
• 細胞内の位置: Secreted, extracellular space: Q56F26
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 223779.85

構造登録者

Pluvinage, B.,Ghinet, M.G.,Brzezinski, R.,Boraston, A.B.,Stubbs, K.A. (登録日: 2009-12-05, 公開日: 2009-12-15, 最終更新日: 2024-11-06)

主引用文献

Pluvinage, B.,Ghinet, M.G.,Brzezinski, R.,Boraston, A.B.,Stubbs, K.A.
Inhibition of the Exo-Beta-D-Glucosaminidase Csxa by a Glucosamine-Configured Castanospermine and an Amino-Australine Analogue.
Org.Biomol.Chem., 7:4169-, 2009

PubMed Abstract: The synthesis of amino-derivatives of castanospermine and australine and their characterisation as inhibitors of the exo-beta-D-glucosaminidase CsxA through enzyme kinetics and X-ray structural analysis is described.

PubMed: 19795054
DOI: 10.1039/B913235J

実験手法

X-RAY DIFFRACTION (2.3 Å)