2WV9
Crystal Structure of the NS3 protease-helicase from Murray Valley encephalitis virus
Summary for 2WV9
Entry DOI | 10.2210/pdb2wv9/pdb |
Related | 2V8O |
Descriptor | FLAVIVIRIN PROTEASE NS2B REGULATORY SUBUNIT, FLAVIVIRIN PROTEASE NS3 CATALYTIC SUBUNIT (2 entities in total) |
Functional Keywords | nucleotide-binding, capsid protein, rna replication, envelope protein, virion, helicase, hydrolase, flavivirus, nucleotidyltransferase |
Biological source | MURRAY VALLEY ENCEPHALITIS VIRUS |
Cellular location | Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P05769 |
Total number of polymer chains | 1 |
Total formula weight | 74056.55 |
Authors | Assenberg, R.,Mastrangelo, E.,Walter, T.S.,Verma, A.,Milani, M.,Owens, R.J.,Stuart, D.I.,Grimes, J.M.,Mancini, E.J. (deposition date: 2009-10-15, release date: 2009-12-01, Last modification date: 2023-12-20) |
Primary citation | Assenberg, R.,Mastrangelo, E.,Walter, T.S.,Verma, A.,Milani, M.,Owens, R.J.,Stuart, D.I.,Grimes, J.M.,Mancini, E.J. Crystal Structure of a Novel Conformational State of the Flavivirus Ns3 Protein: Implications for Polyprotein Processing and Viral Replication. J.Virol., 83:12895-, 2009 Cited by PubMed: 19793813DOI: 10.1128/JVI.00942-09 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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