2WV9

Crystal Structure of the NS3 protease-helicase from Murray Valley encephalitis virus

2WV9 の概要

• エントリーDOI: 10.2210/pdb2wv9/pdb
• 関連するPDBエントリー: 2V8O
• 分子名称: FLAVIVIRIN PROTEASE NS2B REGULATORY SUBUNIT, FLAVIVIRIN PROTEASE NS3 CATALYTIC SUBUNIT (2 entities in total)
• 機能のキーワード: nucleotide-binding, capsid protein, rna replication, envelope protein, virion, helicase, hydrolase, flavivirus, nucleotidyltransferase
• 由来する生物種: MURRAY VALLEY ENCEPHALITIS VIRUS
• 細胞内の位置: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P05769
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 74056.55

構造登録者

Assenberg, R.,Mastrangelo, E.,Walter, T.S.,Verma, A.,Milani, M.,Owens, R.J.,Stuart, D.I.,Grimes, J.M.,Mancini, E.J. (登録日: 2009-10-15, 公開日: 2009-12-01, 最終更新日: 2023-12-20)

• 主引用文献: Assenberg, R.,Mastrangelo, E.,Walter, T.S.,Verma, A.,Milani, M.,Owens, R.J.,Stuart, D.I.,Grimes, J.M.,Mancini, E.J.; Crystal Structure of a Novel Conformational State of the Flavivirus Ns3 Protein: Implications for Polyprotein Processing and Viral Replication.; J.Virol., 83:12895-, 2009; PubMed: 19793813; DOI: 10.1128/JVI.00942-09

実験手法

X-RAY DIFFRACTION (2.75 Å)