2WQL

CRYSTAL STRUCTURE OF THE MAJOR CARROT ALLERGEN DAU C 1

「2VJG」から置き換えられました

2WQL の概要

• エントリーDOI: 10.2210/pdb2wql/pdb
• 分子名称: MAJOR ALLERGEN DAU C 1, O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• 機能のキーワード: pathogenesis-related protein, allergen, plant defense
• 由来する生物種: DAUCUS CAROTA (CARROT)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 66842.04

構造登録者

Markovic-Housley, Z.,Basle, A.,Padavattan, S.,Hoffmann-Sommergruber, K.,Schirmer, T. (登録日: 2009-08-24, 公開日: 2009-09-01, 最終更新日: 2023-12-20)

主引用文献

Markovic-Housley, Z.,Basle, A.,Padavattan, S.,Maderegger, B.,Schirmer, T.,Hoffmann-Sommergruber, K.
Structure of the Major Carrot Allergen Dau C 1.
Acta Crystallogr.,Sect.D, 65:1206-, 2009

PubMed Abstract: Dau c 1 is a major allergen of carrot (Daucus carota) which displays IgE cross-reactivity with the homologous major birch-pollen allergen Bet v 1. The crystal structure of Dau c 1 has been determined to a resolution of 2.7 A, revealing tight dimers. The structure of Dau c 1 is similar to those of the major allergens from celery, Api g 1, and birch pollen, Bet v 1. Electron density has been observed in the hydrophobic cavity of each monomer and has been modelled with polyethylene glycol oligomers of varying length. Comparison of the surface topology and physicochemical properties of Dau c 1 and Bet v 1 revealed that they may have some, but not all, epitopes in common. This is in agreement with the observation that the majority of carrot-allergic patients have Bet v 1 cross-reactive IgE antibodies, whereas others have Dau c 1-specific IgE antibodies which do not recognize Bet v 1.

PubMed: 19923716
DOI: 10.1107/S0907444909034854

実験手法

X-RAY DIFFRACTION (2.7 Å)