2WP5

Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00065414)

2WP5 の概要

• エントリーDOI: 10.2210/pdb2wp5/pdb
• 関連するPDBエントリー: 2WOI 2WOV 2WOW 2WP6 2WPC 2WPE 2WPF
• 分子名称: TRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, METHYL [(4S)-6-BROMO-2-METHYL-4-PHENYLQUINAZOLIN-3(4H)-YL]ACETATE, ... (8 entities in total)
• 機能のキーワード: oxidoreductase, trypanosomiasis, sleeping sickness, flavoprotein, redox-active center
• 由来する生物種: TRYPANOSOMA BRUCEI
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 219521.31

構造登録者

Alphey, M.S.,Patterson, S.,Fairlamb, A.H. (登録日: 2009-08-03, 公開日: 2010-10-13, 最終更新日: 2023-12-20)

• 主引用文献: Patterson, S.,Alphey, M.S.,Jones, D.C.,Shanks, E.J.,Street, I.P.,Frearson, J.A.,Wyatt, P.G.,Gilbert, I.H.,Fairlamb, A.H.; Dihydroquinazolines as a Novel Class of Trypanosoma Brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of Their Binding Mode by Protein Crystallography.; J.Med.Chem., 54:6514-, 2011; PubMed: 21851087; DOI: 10.1021/JM200312V

実験手法

X-RAY DIFFRACTION (2.8 Å)