2WM1

The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis

2WM1 の概要

• エントリーDOI: 10.2210/pdb2wm1/pdb
• 分子名称: 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE, ZINC ION, 1,3-DIHYDROXYACETONEPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: neurological disorders, metal-dependent amidohydrolase, kynurenine pathway, alternative splicing, quinolinic acid, nad biosynthesis, cerebral malaria, lyase, decarboxylase, picolinic acid, phosphoprotein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38411.78

構造登録者

Garavaglia, S.,Perozzi, S.,Galeazzi, L.,Raffaelli, N.,Rizzi, M. (登録日: 2009-06-29, 公開日: 2009-11-03, 最終更新日: 2023-12-13)

• 主引用文献: Garavaglia, S.,Perozzi, S.,Galeazzi, L.,Raffaelli, N.,Rizzi, M.; The Crystal Structure of Human Alpha-Amino-Beta-Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3-Dihydroxyacetonephosphate Suggests a Regulatory Link between Nad Synthesis and Glycolysis; FEBS J., 276:6615-, 2009; PubMed: 19843166; DOI: 10.1111/J.1742-4658.2009.07372.X

実験手法

X-RAY DIFFRACTION (2.01 Å)