2WH7

The partial structure of a group A streptpcoccal phage-encoded tail fibre hyaluronate lyase Hylp2

2WH7 の概要

• エントリーDOI: 10.2210/pdb2wh7/pdb
• 分子名称: HYALURONIDASE-PHAGE ASSOCIATED (2 entities in total)
• 機能のキーワード: triple-stranded beta-helix, hyaluronan lyase, phage tail fibre, hydrolase, glycosidase, hyaluronidase, scarlet fever
• 由来する生物種: STREPTOCOCCUS PYOGENES
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19118.58

構造登録者

Martinez-Fleites, C.,Black, G.W.,Turkenburg, J.P.,Smith, N.L.,Taylor, E.J. (登録日: 2009-05-01, 公開日: 2009-09-01, 最終更新日: 2023-12-13)

主引用文献

Martinez-Fleites, C.,Smith, N.L.,Turkenburg, J.P.,Black, G.W.,Taylor, E.J.
Structures of Two Truncated Phage-Tail Hyaluronate Lyases from Streptococcus Pyogenes Serotype M1.
Acta Crystallogr.,Sect.F, 65:963-, 2009

PubMed Abstract: The crystal structures of truncated forms of the Streptococcus pyogenes phage-encoded hyaluronate lyases HylP2 and HylP3 were determined by molecular replacement to 1.6 and 1.9 A resolution, respectively. The truncated forms crystallized in a hexagonal space group, forming a trimer around the threefold crystallographic axis. The arrangement of the fold is very similar to that observed in the structure of the related hyaluronate lyase HylP1. The structural elements putatively involved in substrate recognition are found to be conserved in both the HylP2 and HylP3 fragments.

PubMed: 19850999
DOI: 10.1107/S1744309109032813

実験手法

X-RAY DIFFRACTION (1.6 Å)