2WFO

Crystal structure of Machupo virus envelope glycoprotein GP1

2WFO の概要

• エントリーDOI: 10.2210/pdb2wfo/pdb
• 分子名称: GLYCOPROTEIN 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: glycoprotein, arenavirus, new world arenavirus, hemorrhagic fever virus, envelope protein, machupo, junin, guanarito, sabia, chapare, virion, macv, gp1, viral attachment, transferrin receptor, viral protein
• 由来する生物種: Machupo virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22138.96

構造登録者

Bowden, T.A.,Crispin, M.,Graham, S.C.,Harvey, D.J.,Grimes, J.M.,Jones, E.Y.,Stuart, D.I. (登録日: 2009-04-09, 公開日: 2009-06-16, 最終更新日: 2024-11-13)

主引用文献

Bowden, T.A.,Crispin, M.,Graham, S.C.,Harvey, D.J.,Grimes, J.M.,Jones, E.Y.,Stuart, D.I.
Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein.
J.Virol., 83:8259-, 2009

PubMed Abstract: New World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor. This first structure of an arenavirus glycoprotein shows that GP1 consists of a novel alpha/beta fold. This provides a blueprint of the New World arenavirus attachment glycoproteins and reveals a new architecture of viral attachment, using a protein fold of unknown origins.

PubMed: 19494008
DOI: 10.1128/JVI.00761-09

実験手法

X-RAY DIFFRACTION (1.73 Å)