2WFI

Atomic resolution crystal structure of the PPIase domain of human cyclophilin G

2WFI の概要

• エントリーDOI: 10.2210/pdb2wfi/pdb
• 関連するPDBエントリー: 2GW2 2WFJ
• 分子名称: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: phosphoprotein, pre-mrna splicing, alternative splicing, nucleus, rotamase, isomerase, cyclosporin, peptidyl-prolyl cis-trans isomerase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19940.13

構造登録者

Stegmann, C.M.,Sheldrick, G.M.,Wahl, M.C. (登録日: 2009-04-06, 公開日: 2009-06-16, 最終更新日: 2019-05-22)

主引用文献

Stegmann, C.M.,Seeliger, D.,Sheldrick, G.M.,De Groot, B.L.,Wahl, M.C.
The Thermodynamic Influence of Trapped Water Molecules on a Protein-Ligand Interaction
Angew.Chem.Int.Ed.Engl., 48:5207-, 2009

PubMed Abstract: Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex with cyclosporin A, and together with MD simulations and calorimetry, reveal how trapped water molecules influence the thermodynamic profile of a protein-ligand interaction.

PubMed: 19499554
DOI: 10.1002/ANIE.200900481

実験手法

X-RAY DIFFRACTION (0.75 Å)