2WFG

Structure of the Candida albicans cytosolic leucyl-tRNA synthetase editing domain bound to a benzoxaborole-AMP adduct

2WFG の概要

• エントリーDOI: 10.2210/pdb2wfg/pdb
• 関連するPDBエントリー: 2WFE
• 分子名称: CYTOSOLIC LEUCYL-TRNA SYNTHETASE, [(1S,3S,5R,6R,8R)-6-(6-AMINOPURIN-9-YL)-4'-ETHYLAMINO-3'-FLUORO-SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,7'-8-OXA-7-BORANUIDABICYCLO[4.3.0]NONA-1,3,5-TRIENE]-8-YL]METHYL DIHYDROGEN PHOSPHATE (3 entities in total)
• 機能のキーワード: ligase, leucyl-trna synthetase, editing domain, candida albicans, hydrolysis of mis-charged trnas, benzoxaborole, anti-fungal
• 由来する生物種: CANDIDA ALBICANS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30019.81

構造登録者

Seiradake, E.,Mao, W.,Hernandez, V.,Baker, S.J.,Plattner, J.J.,Alley, M.R.K.,Cusack, S. (登録日: 2009-04-05, 公開日: 2009-05-19, 最終更新日: 2011-07-13)

• 主引用文献: Seiradake, E.,Mao, W.,Hernandez, V.,Baker, S.J.,Plattner, J.J.,Alley, M.R.K.,Cusack, S.; Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles.; J.Mol.Biol., 390:196-, 2009; PubMed: 19426743; DOI: 10.1016/J.JMB.2009.04.073

実験手法

X-RAY DIFFRACTION (2.2 Å)