2WFG

Structure of the Candida albicans cytosolic leucyl-tRNA synthetase editing domain bound to a benzoxaborole-AMP adduct

2WFG の概要

関連するPDBエントリー2WFE
分子名称CYTOSOLIC LEUCYL-TRNA SYNTHETASE, [(1S,3S,5R,6R,8R)-6-(6-AMINOPURIN-9-YL)-4'-ETHYLAMINO-3'-FLUORO-SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,7'-8-OXA-7-BORANUIDABICYCLO[4.3.0]NONA-1,3,5-TRIENE]-8-YL]METHYL DIHYDROGEN PHOSPHATE (3 entities in total)
機能のキーワードligase, leucyl-trna synthetase, editing domain, candida albicans, hydrolysis of mis-charged trnas, benzoxaborole, anti-fungal
由来する生物種CANDIDA ALBICANS
ポリマー鎖数1
分子量合計30019.81
構造登録者
Seiradake, E.,Mao, W.,Hernandez, V.,Baker, S.J.,Plattner, J.J.,Alley, M.R.K.,Cusack, S. (登録日: 2009-04-05, 公開日: 2009-05-19, 最終更新日: 2011-07-13)
主引用文献
Seiradake, E.,Mao, W.,Hernandez, V.,Baker, S.J.,Plattner, J.J.,Alley, M.R.K.,Cusack, S.
Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles.
J.Mol.Biol., 390:196-, 2009
PubMed: 19426743 (主引用文献が同じPDBエントリー)
DOI: 10.1016/J.JMB.2009.04.073
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.2 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.282302.8%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード

他の静止画像(非対称単位)

Molmil generated image of 2wfg
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Molmil generated image of 2wfg
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Molmil generated image of 2wfg
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