2WFD

Structure of the human cytosolic leucyl-tRNA synthetase editing domain

Summary for 2WFD

Entry DOI	10.2210/pdb2wfd/pdb
Descriptor	LEUCYL-TRNA SYNTHETASE, CYTOPLASMIC (1 entity in total)
Functional Keywords	aminoacyl-trna synthetase, phosphoprotein, editing domain, nucleotide-binding, hydrolysis of mis-charged trnas, protein biosynthesis, leucyl-trna synthetase, human, ligase, cytoplasm, atp-binding, polymorphism
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm (By similarity): Q9P2J5
Total number of polymer chains	2
Total formula weight	56943.39
Authors	Seiradake, E.,Mao, W.,Hernandez, V.,Baker, S.J.,Plattner, J.J.,Alley, M.R.K.,Cusack, S. (deposition date: 2009-04-03, release date: 2009-05-19, Last modification date: 2011-07-13)
Primary citation	Seiradake, E.,Mao, W.,Hernandez, V.,Baker, S.J.,Plattner, J.J.,Alley, M.R.K.,Cusack, S. Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles. J.Mol.Biol., 390:196-, 2009 Cited by PubMed: 19426743 DOI: 10.1016/J.JMB.2009.04.073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation