2WA5
Crystal structure of human filamin B actin binding domain at 1.9 Angstroms resolution
2WA5 の概要
エントリーDOI | 10.2210/pdb2wa5/pdb |
関連するPDBエントリー | 2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2WA6 2WA7 |
分子名称 | FILAMIN-B, SULFATE ION, CARBONATE ION, ... (4 entities in total) |
機能のキーワード | disease mutation, skeletal dysplasia, structural protein, actin-crosslinking, myogenesis, cytoskeleton, actin-binding, calponin homology domain, phosphoprotein, differentiation, atelosteogenesis, mutant, filamin, dwarfism, ch domain, developmental protein |
由来する生物種 | HOMO SAPIENS (HUMAN) |
細胞内の位置 | Isoform 1: Cytoplasm, cell cortex. Isoform 2: Cytoplasm, cytoskeleton. Isoform 3: Cytoplasm, cytoskeleton. Isoform 6: Cytoplasm, cytoskeleton: O75369 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 28471.28 |
構造登録者 | Sawyer, G.M.,Clark, A.R.,Robertson, S.P.,Sutherland-Smith, A.J. (登録日: 2009-02-03, 公開日: 2009-06-23, 最終更新日: 2023-12-13) |
主引用文献 | Sawyer, G.M.,Clark, A.R.,Robertson, S.P.,Sutherland-Smith, A.J. Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains. J.Mol.Biol., 390:1030-, 2009 Cited by PubMed: 19505475DOI: 10.1016/J.JMB.2009.06.009 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード