2W0W

Crystal structure of Glmu from Haemophilus influenzae in complex with quinazoline inhibitor 2

2W0W の概要

• エントリーDOI: 10.2210/pdb2w0w/pdb
• 関連するPDBエントリー: 2V0H 2V0I 2V0J 2V0K 2V0L 2VD4 2W0V
• 分子名称: GLUCOSAMINE-1-PHOSPHATE N-ACETYLTRANSFERASE, N-{6-(CYCLOPROPYLMETHOXY)-7-METHOXY-2-[6-(2-METHYLPROPYL)-5-OXO-3,4,5,6-TETRAHYDRO-2,6-NAPHTHYRIDIN-2(1H)-YL]QUINAZOLIN-4-YL}-2,2,2-TRIFLUOROETHANESULFONAMIDE, TETRAETHYLENE GLYCOL, ... (4 entities in total)
• 機能のキーワード: peptidoglycan synthesis, glmu, bacterial, inhibitor, magnesium, cell shape, transferase, active site, metal-binding, cell wall biogenesis/degradation, multifunctional enzyme, nucleotidyltransferase, acyltransferase, uridyltransferase
• 由来する生物種: HAEMOPHILUS INFLUENZAE
• 細胞内の位置: Cytoplasm (By similarity): P43889
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50135.92

構造登録者

Mochalkin, I.,Melnick, M. (登録日: 2008-10-10, 公開日: 2009-11-17, 最終更新日: 2023-12-13)

• 主引用文献: Melnick, M.,Mochalkin, I.,Lightle, S.,Narasimhan, L.,Mcdowell, L.,Sarver, R.; Discovery and Initial Sar of Quinazoline Inhibitors of Glmu from Haemophilus Influenzae; To be Published,

実験手法

X-RAY DIFFRACTION (2.59 Å)