2W0V
Crystal structure of Glmu from Haemophilus influenzae in complex with quinazoline inhibitor 1
Summary for 2W0V
Entry DOI | 10.2210/pdb2w0v/pdb |
Related | 2V0H 2V0I 2V0J 2V0K 2V0L 2VD4 2W0W |
Descriptor | GLUCOSAMINE-1-PHOSPHATE N-ACETYLTRANSFERASE, 6-(CYCLOPROP-2-EN-1-YLMETHOXY)-2-[6-(CYCLOPROPYLMETHYL)-5-OXO-3,4,5,6-TETRAHYDRO-2,6-NAPHTHYRIDIN-2(1H)-YL]-7-METHOXYQUINAZOLIN-4(3H)-ONE, TETRAETHYLENE GLYCOL, ... (6 entities in total) |
Functional Keywords | peptidoglycan synthesis, glmu, bacterial, inhibitor, magnesium, cell shape, transferase, active site, metal-binding, cell wall biogenesis/degradation, multifunctional enzyme, nucleotidyltransferase, acyltransferase, uridyltransferase |
Biological source | HAEMOPHILUS INFLUENZAE |
Cellular location | Cytoplasm (By similarity): P43889 |
Total number of polymer chains | 1 |
Total formula weight | 50863.51 |
Authors | Mochalkin, I.,Melnick, M. (deposition date: 2008-10-10, release date: 2009-11-17, Last modification date: 2023-12-13) |
Primary citation | Melnick, M.,Mochalkin, I.,Lightle, S.,Narasimhan, L.,Mcdowell, L.,Sarver, R. Discovery and Initial Sar of Quinazoline Inhibitors of Glmu from Haemophilus Influenzae To be Published, |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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