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2W0V

Crystal structure of Glmu from Haemophilus influenzae in complex with quinazoline inhibitor 1

2W0V の概要
エントリーDOI10.2210/pdb2w0v/pdb
関連するPDBエントリー2V0H 2V0I 2V0J 2V0K 2V0L 2VD4 2W0W
分子名称GLUCOSAMINE-1-PHOSPHATE N-ACETYLTRANSFERASE, 6-(CYCLOPROP-2-EN-1-YLMETHOXY)-2-[6-(CYCLOPROPYLMETHYL)-5-OXO-3,4,5,6-TETRAHYDRO-2,6-NAPHTHYRIDIN-2(1H)-YL]-7-METHOXYQUINAZOLIN-4(3H)-ONE, TETRAETHYLENE GLYCOL, ... (6 entities in total)
機能のキーワードpeptidoglycan synthesis, glmu, bacterial, inhibitor, magnesium, cell shape, transferase, active site, metal-binding, cell wall biogenesis/degradation, multifunctional enzyme, nucleotidyltransferase, acyltransferase, uridyltransferase
由来する生物種HAEMOPHILUS INFLUENZAE
細胞内の位置Cytoplasm (By similarity): P43889
タンパク質・核酸の鎖数1
化学式量合計50863.51
構造登録者
Mochalkin, I.,Melnick, M. (登録日: 2008-10-10, 公開日: 2009-11-17, 最終更新日: 2023-12-13)
主引用文献Melnick, M.,Mochalkin, I.,Lightle, S.,Narasimhan, L.,Mcdowell, L.,Sarver, R.
Discovery and Initial Sar of Quinazoline Inhibitors of Glmu from Haemophilus Influenzae
To be Published,
実験手法
X-RAY DIFFRACTION (1.99 Å)
構造検証レポート
Validation report summary of 2w0v
検証レポート(詳細版)ダウンロードをダウンロード

223532

件を2024-08-07に公開中

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