2W0T

Solution structure of the FCS zinc finger domain of human LMBL2

2W0T の概要

• エントリーDOI: 10.2210/pdb2w0t/pdb
• 分子名称: LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE 2 PROTEIN, ZINC ION (2 entities in total)
• 機能のキーワード: zinc, yacg, lmbl2, nucleus, zinc-finger, rna binding, mbt repeats, pcg proteins, polymorphism, transcription, mym zinc finger, treble clef fold, chromatin regulator, human lethal(3) malignant brain tumor 2 protein, alternative splicing, transcription regulation, metal-binding, phosphoprotein, polycomb group
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : Q969R5
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4672.64

構造登録者

Lechtenberg, B.C.,Allen, M.D.,Bycroft, M. (登録日: 2008-10-10, 公開日: 2009-01-20, 最終更新日: 2024-05-15)

主引用文献

Lechtenberg, B.C.,Allen, M.D.,Rutherford, T.J.,Freund, S.M.,Bycroft, M.
Solution Structure of the Fcs Zinc Finger Domain of the Human Polycomb Group Protein L(3)Mbt-Like 2.
Protein Sci., 18:657-, 2009

PubMed Abstract: Polycomb group proteins are epigenetic regulators that maintain patterns of gene expression over multiple rounds of cell division. Many of these proteins, including polyhomeotic and the MBT repeat containing proteins SCM and dSfmbt, contain an atypical C2C2 zinc finger with a characteristic phenylalanine-cysteine-serine sequence motif. The reoccurrence of this so-called FCS zinc finger in a variety of polycomb group proteins suggests that it has an important regulatory function. We have determined the solution structure of the FCS zinc finger of the human dSfmbt homologue L(3)mbt-like 2 (L3MBTL2). The structure consists of a beta-hairpin followed by an alpha-helix. The zinc ligands are situated in the beta-hairpin and at the N-terminus of the alpha-helix an arrangement typical of the treble clef class of zinc fingers. The structure is consistent with the proposal that FCS zinc fingers bind to regulatory RNAs.

PubMed: 19241375
DOI: 10.1002/PRO.51

実験手法

SOLUTION NMR