2VY9

Molecular architecture of the stressosome, a signal integration and transduction hub

2VY9 の概要

• エントリーDOI: 10.2210/pdb2vy9/pdb
• 分子名称: ANTI-SIGMA-FACTOR ANTAGONIST (2 entities in total)
• 機能のキーワード: moorella thermoacetica, gene regulation, rsbs, stressosome, stas domain, bacillus subtilis
• 由来する生物種: MOORELLA THERMOACETICA
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27537.09

構造登録者

Marles-Wright, J.,Grant, T.,Delumeau, O.,van Duinen, G.,Firbank, S.J.,Lewis, P.J.,Murray, J.W.,Newman, J.A.,Quin, M.B.,Race, P.R.,Rohou, A.,Tichelaar, W.,van Heel, M.,Lewis, R.J. (登録日: 2008-07-21, 公開日: 2008-10-14, 最終更新日: 2024-10-16)

主引用文献

Marles-Wright, J.,Grant, T.,Delumeau, O.,Van Duinen, G.,Firbank, S.J.,Lewis, P.J.,Murray, J.W.,Newman, J.A.,Quin, M.B.,Race, P.R.,Rohou, A.,Tichelaar, W.,Van Heel, M.,Lewis, R.J.
Molecular Architecture of the "Stressosome," a Signal Integration and Transduction Hub
Science, 322:92-, 2008

PubMed Abstract: A commonly used strategy by microorganisms to survive multiple stresses involves a signal transduction cascade that increases the expression of stress-responsive genes. Stress signals can be integrated by a multiprotein signaling hub that responds to various signals to effect a single outcome. We obtained a medium-resolution cryo-electron microscopy reconstruction of the 1.8-megadalton "stressosome" from Bacillus subtilis. Fitting known crystal structures of components into this reconstruction gave a pseudoatomic structure, which had a virus capsid-like core with sensory extensions. We suggest that the different sensory extensions respond to different signals, whereas the conserved domains in the core integrate the varied signals. The architecture of the stressosome provides the potential for cooperativity, suggesting that the response could be tuned dependent on the magnitude of chemophysical insult.

PubMed: 18832644
DOI: 10.1126/SCIENCE.1159572

実験手法

X-RAY DIFFRACTION (2.3 Å)