2VX0

ephB4 kinase domain inhibitor complex

2VX0 の概要

• エントリーDOI: 10.2210/pdb2vx0/pdb
• 関連するPDBエントリー: 2BBA 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX1
• 分子名称: EPHRIN TYPE-B RECEPTOR 4, N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: mutant, membrane, transferase, atp-binding, polymorphism, glycoprotein, transmembrane, phosphoprotein, unphosphorylated, nucleotide-binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34433.60

構造登録者

Read, J.,Brassington, C.A.,Green, I.,McCall, E.J.,Valentine, A.L.,Barratt, D.,Leach, A.G.,Kettle, J.G. (登録日: 2008-06-30, 公開日: 2008-10-28, 最終更新日: 2023-12-13)

• 主引用文献: Bardelle, C.,Cross, D.,Davenport, S.,Kettle, J.G.,Ko, E.J.,Leach, A.G.,Mortlock, A.,Read, J.,Roberts, N.J.,Robins, P.,Williams, E.J.; Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines.; Bioorg.Med.Chem.Lett., 18:2776-, 2008; PubMed: 18434142; DOI: 10.1016/J.BMCL.2008.04.015

実験手法

X-RAY DIFFRACTION (2.1 Å)