2VSG

A Structural Motif in the Variant Surface Glycoproteins of Trypanosoma Brucei

2VSG の概要

• エントリーDOI: 10.2210/pdb2vsg/pdb
• 関連するPDBエントリー: 1VSG
• 分子名称: VARIANT SURFACE GLYCOPROTEIN ILTAT 1.24 (2 entities in total)
• 機能のキーワード: vsg, trypanosome, antigenic variation, membrane protein
• 由来する生物種: Trypanosoma brucei
• 細胞内の位置: Cell membrane; Lipid-anchor, GPI-anchor: P26329
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76573.48

構造登録者

Blum, M.L.,Down, J.A.,Metcalf, P.,Freymann, D.M.,Wiley, D.C. (登録日: 1998-11-19, 公開日: 1998-11-25, 最終更新日: 2024-10-16)

主引用文献

Blum, M.L.,Down, J.A.,Gurnett, A.M.,Carrington, M.,Turner, M.J.,Wiley, D.C.
A structural motif in the variant surface glycoproteins of Trypanosoma brucei.
Nature, 362:603-609, 1993

PubMed Abstract: The variable domain of the trypanosome variant surface glycoprotein (VSG) ILTat 1.24 has been shown by X-ray crystallography to resemble closely the structures of VSG MITat 1.2, despite their low sequence similarity. Specific structural features of these VSGs, including substitution of carbohydrate for an alpha-helix, can be found in other VSG sequences. Thus antigenic variation in trypanosomes is accomplished by sequence variation, not gross structural alteration; the extensive sequence differences among VSGs may be required for another reason, such as the avoidance of recognition by helper T cells. Additionally, VSG sequences are found to define families, within a VSG superfamily, which have evolved in the trypanosome genome.

PubMed: 8464512
DOI: 10.1038/362603a0

実験手法

X-RAY DIFFRACTION (2.7 Å)