2VP3

DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG

Summary for 2VP3

Entry DOI	10.2210/pdb2vp3/pdb
Descriptor	VP39, S-ADENOSYL-L-HOMOCYSTEINE, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	methyltransferase, rna cap, poly(a) polymerase, vaccinia, mrna processing, transcription
Biological source	Vaccinia virus
Total number of polymer chains	1
Total formula weight	37976.35
Authors	Hodel, A.E.,Gershon, P.D.,Quiocho, F.A. (deposition date: 1996-12-16, release date: 1997-09-17, Last modification date: 2024-03-06)
Primary citation	Hodel, A.E.,Gershon, P.D.,Shi, X.,Wang, S.M.,Quiocho, F.A. Specific protein recognition of an mRNA cap through its alkylated base. Nat.Struct.Biol., 4:350-354, 1997 Cited by PubMed Abstract: The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap. PubMed: 9145102 DOI: 10.1038/nsb0597-350 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation