2VM6

Human Bcl2-A1 in complex with Bim-BH3 peptide

Summary for 2VM6

• Entry DOI: 10.2210/pdb2vm6/pdb
• Related: 2V6Q 2VM5
• Descriptor: BCL-2-RELATED PROTEIN A1, BCL-2-LIKE PROTEIN 11, SULFATE ION, ... (4 entities in total)
• Functional Keywords: b-cell lymphoma2, antiapoptotic, immune system, bim, bfl-1, bcl2a1, bcl-2a1, membrane, apoptosis
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 20460.18

Authors

Herman, M.D.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Kallas, A.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nyman, T.,Persson, C.,Sagemark, J.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,van den Berg, S.,Weigelt, J.,Welin, M.,Nordlund, P.,Structural Genomics Consortium (SGC) (deposition date: 2008-01-23, release date: 2008-02-05, Last modification date: 2024-05-08)

Primary citation

Herman, M.D.,Nyman, T.,Welin, M.,Lehtio, L.,Flodin, S.,Tresaugues, L.,Kotenyova, T.,Flores, A.,Nordlund, P.
Completing the Family Portrait of the Anti- Apoptotic Bcl-2 Proteins: Crystal Structure of Human Bfl-1 in Complex with Bim.
FEBS Lett., 582:3590-, 2008

PubMed Abstract: Evasion of apoptosis is recognized as a characteristic of malignant growth. Anti-apoptotic B-cell lymphoma-2 (Bcl-2) family members have therefore emerged as potential therapeutic targets due to their critical role in proliferating cancer cells. Here, we present the crystal structure of Bfl-1, the last anti-apoptotic Bcl-2 family member to be structurally characterized, in complex with a peptide corresponding to the BH3 region of the pro-apoptotic protein Bim. The structure reveals distinct features at the peptide-binding site, likely to define the binding specificity for pro-apoptotic proteins. Superposition of the Bfl-1:Bim complex with that of Mcl-1:Bim reveals a significant local plasticity of hydrophobic interactions contributed by the Bim peptide, likely to be the basis for the multi specificity of Bim for anti-apoptotic proteins.

PubMed: 18812174
DOI: 10.1016/J.FEBSLET.2008.09.028

Experimental method

X-RAY DIFFRACTION (2.2 Å)