2VM6

Human Bcl2-A1 in complex with Bim-BH3 peptide

2VM6 の概要

• エントリーDOI: 10.2210/pdb2vm6/pdb
• 関連するPDBエントリー: 2V6Q 2VM5
• 分子名称: BCL-2-RELATED PROTEIN A1, BCL-2-LIKE PROTEIN 11, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: b-cell lymphoma2, antiapoptotic, immune system, bim, bfl-1, bcl2a1, bcl-2a1, membrane, apoptosis
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20460.18

構造登録者

Herman, M.D.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Kallas, A.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nyman, T.,Persson, C.,Sagemark, J.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,van den Berg, S.,Weigelt, J.,Welin, M.,Nordlund, P.,Structural Genomics Consortium (SGC) (登録日: 2008-01-23, 公開日: 2008-02-05, 最終更新日: 2024-05-08)

主引用文献

Herman, M.D.,Nyman, T.,Welin, M.,Lehtio, L.,Flodin, S.,Tresaugues, L.,Kotenyova, T.,Flores, A.,Nordlund, P.
Completing the Family Portrait of the Anti- Apoptotic Bcl-2 Proteins: Crystal Structure of Human Bfl-1 in Complex with Bim.
FEBS Lett., 582:3590-, 2008

PubMed Abstract: Evasion of apoptosis is recognized as a characteristic of malignant growth. Anti-apoptotic B-cell lymphoma-2 (Bcl-2) family members have therefore emerged as potential therapeutic targets due to their critical role in proliferating cancer cells. Here, we present the crystal structure of Bfl-1, the last anti-apoptotic Bcl-2 family member to be structurally characterized, in complex with a peptide corresponding to the BH3 region of the pro-apoptotic protein Bim. The structure reveals distinct features at the peptide-binding site, likely to define the binding specificity for pro-apoptotic proteins. Superposition of the Bfl-1:Bim complex with that of Mcl-1:Bim reveals a significant local plasticity of hydrophobic interactions contributed by the Bim peptide, likely to be the basis for the multi specificity of Bim for anti-apoptotic proteins.

PubMed: 18812174
DOI: 10.1016/J.FEBSLET.2008.09.028

実験手法

X-RAY DIFFRACTION (2.2 Å)