Summary for 2VIR
| Entry DOI | 10.2210/pdb2vir/pdb |
| Descriptor | IMMUNOGLOBULIN (IGG1, LAMBDA), HEMAGGLUTININ, ZINC ION, ... (4 entities in total) |
| Functional Keywords | complex (hemagglutinin-immunoglobulin), glycoprotein, complex (hemagglutinin-immunoglobulin) complex, complex (hemagglutinin/immunoglobulin) |
| Biological source | Influenza A virus (A/X-31(H3N2)) More |
| Cellular location | Virion membrane; Single-pass type I membrane protein (Potential): P03437 |
| Total number of polymer chains | 3 |
| Total formula weight | 77737.90 |
| Authors | Bizebard, T.,Fleury, D.,Gigant, B.,Wharton, S.A.,Skehel, J.J.,Knossow, M. (deposition date: 1997-12-22, release date: 1998-04-29, Last modification date: 2024-10-23) |
| Primary citation | Fleury, D.,Wharton, S.A.,Skehel, J.J.,Knossow, M.,Bizebard, T. Antigen distortion allows influenza virus to escape neutralization. Nat.Struct.Biol., 5:119-123, 1998 Cited by PubMed Abstract: The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies. PubMed: 9461077DOI: 10.1038/nsb0298-119 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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