2VCD

Solution structure of the FKBP-domain of Legionella pneumophila Mip in complex with rapamycin

2VCD の概要

• エントリーDOI: 10.2210/pdb2vcd/pdb
• NMR情報: BMRB: 15507
• 分子名称: Outer membrane protein MIP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG (2 entities in total)
• 機能のキーワード: mip, fkbp, ppiase, membrane, rotamase, sirolimus, virulence, isomerase, rapamycin, fkbp-domain, outer membrane, legionnaires disease, macrolide antibiotic, legionella pneumophila
• 由来する生物種: Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
• 細胞内の位置: Cell outer membrane: Q5ZXE0
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15581.87

構造登録者

Ceymann, A.,Horstmann, M.,Ehses, P.,Schweimer, K.,Paschke, A.-K.,Fischer, G.,Roesch, P.,Faber, C. (登録日: 2007-09-20, 公開日: 2008-09-02, 最終更新日: 2024-05-15)

主引用文献

Ceymann, A.,Horstmann, M.,Ehses, P.,Schweimer, K.,Paschke, A.K.,Steinert, M.,Faber, C.
Solution structure of the Legionella pneumophila Mip-rapamycin complex.
BMC Struct. Biol., 8:17-17, 2008

PubMed Abstract: Legionella pneumphila is the causative agent of Legionnaires' disease. A major virulence factor of the pathogen is the homodimeric surface protein Mip. It shows peptidyl-prolyl cis/trans isomerase activty and is a receptor of FK506 and rapamycin, which both inhibit its enzymatic function. Insight into the binding process may be used for the design of novel Mip inhibitors as potential drugs against Legionnaires' disease.

PubMed: 18366641
DOI: 10.1186/1472-6807-8-17

実験手法

SOLUTION NMR