2VAJ

Crystal structure of NCAM2 Ig1 (I4122 cell unit)

2VAJ の概要

• エントリーDOI: 10.2210/pdb2vaj/pdb
• 関連するPDBエントリー: 2DOC 2V44 2V5T 2VA4
• 分子名称: NEURAL CELL ADHESION MOLECULE 2 (2 entities in total)
• 機能のキーワード: immunoglobulin domain, cell adhesion
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: O15394
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10364.62

構造登録者

Kulahin, N.,Rasmussen, K.K.,Kristensen, O.,Kastrup, J.S.,Navarro-Poulsen, J.-C.,Berezin, V.,Bock, E.,Walmod, P.S.,Gajhede, M. (登録日: 2007-08-31, 公開日: 2008-08-26, 最終更新日: 2024-10-23)

主引用文献

Rasmussen, K.K.,Kulahin, N.,Kristensen, O.,Poulsen, J.C.,Sigurskjold, B.W.,Kastrup, J.S.,Berezin, V.,Bock, E.,Walmod, P.S.,Gajhede, M.
Crystal Structure of the Ig1 Domain of the Neural Cell Adhesion Molecule Ncam2 Displays Domain Swapping.
J.Mol.Biol., 382:1113-, 2008

PubMed Abstract: The crystal structure of the first immunoglobulin (Ig1) domain of neural cell adhesion molecule 2 (NCAM2/OCAM/RNCAM) is presented at a resolution of 2.7 A. NCAM2 is a member of the immunoglobulin superfamily of cell adhesion molecules (IgCAMs). In the structure, two Ig domains interact by domain swapping, as the two N-terminal beta-strands are interchanged. beta-Strand swapping at the terminal domain is the accepted mechanism of homophilic interactions amongst the cadherins, another class of CAMs, but it has not been observed within the IgCAM superfamily. Gel-filtration chromatography demonstrated the ability of NCAM2 Ig1 to form dimers in solution. Taken together, these observations suggest that beta-strand swapping could have a role in the molecular mechanism of homophilic binding for NCAM2.

PubMed: 18706912
DOI: 10.1016/J.JMB.2008.07.084

実験手法

X-RAY DIFFRACTION (2.701 Å)