2V0E

BRK domain from human CHD7

2V0E の概要

• エントリーDOI: 10.2210/pdb2v0e/pdb
• 関連するPDBエントリー: 2CKC 2V0F
• 分子名称: CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 7 (1 entity in total)
• 機能のキーワード: nucleotide-binding, chromatin regulator, charge syndrome, phosphorylation, disease mutation, transcription regulation, chd7, helicase, hydrolase, brk domain, atp-binding, dna-binding, transcription, nuclear protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus, nucleolus : Q9P2D1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6169.90

構造登録者

Allen, M.D.,Religa, T.L.,Freund, S.M.V.,Bycroft, M. (登録日: 2007-05-14, 公開日: 2007-05-22, 最終更新日: 2024-05-15)

主引用文献

Allen, M.D.,Religa, T.L.,Freund, S.M.V.,Bycroft, M.
Solution Structure of the Brk Domains from Chd7
J.Mol.Biol., 371:1135-, 2007

PubMed Abstract: CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact betabetaalphabeta fold. The second domain has a C-terminal extension consisting of two additional helices. The structure differs from those of other domains present in chromatin-associated proteins.

PubMed: 17603073
DOI: 10.1016/J.JMB.2007.06.007

実験手法

SOLUTION NMR