2TOH

TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT

Summary for 2TOH

Entry DOI	10.2210/pdb2toh/pdb
Descriptor	TYROSINE 3-MONOOXYGENASE, FE (III) ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hydroxylase, neurotransmitter biosynthesis, non-heme iron, pterin co-substrate, catecholamine biosynthesis, oxidoreductase
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	1
Total formula weight	39620.62
Authors	Goodwill, K.E.,Sabatier, C.,Stevens, R.C. (deposition date: 1998-08-26, release date: 1999-08-26, Last modification date: 2024-04-03)
Primary citation	Goodwill, K.E.,Sabatier, C.,Stevens, R.C. Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site. Biochemistry, 37:13437-13445, 1998 Cited by PubMed: 9753429 DOI: 10.1021/bi981462g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation