2RRQ

DNA oligomer containing propylene cross-linked cyclic 2'-deoxyuridylate dimer

2RRQ の概要

• エントリーDOI: 10.2210/pdb2rrq/pdb
• 関連するPDBエントリー: 2RRR
• NMR情報: BMRB: 11437
• 分子名称: DNA (5'-D(*CP*CP*TP*TP*CP*AP*(JDT)P*TP*AP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*GP*TP*AP*AP*TP*GP*AP*AP*GP*G)-3') (2 entities in total)
• 機能のキーワード: dna, nucleic acid, deoxyuridylate, bent dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 8573.63

構造登録者

Furuita, K.,Murata, S.,Jee, J.G.,Ichikawa, S.,Matsuda, A.,Kojima, C. (登録日: 2011-03-24, 公開日: 2011-06-08, 最終更新日: 2024-05-15)

主引用文献

Furuita, K.,Murata, S.,Jee, J.G.,Ichikawa, S.,Matsuda, A.,Kojima, C.
Structural Feature of Bent DNA Recognized by HMGB1
J.Am.Chem.Soc., 133:5788-5790, 2011

PubMed Abstract: High Mobility Group Box 1 (HMGB1) protein, a potential therapeutic target, binds bent DNAs structure-specifically. Here we report on a crucial structural feature of the bent DNA required for strong binding to HMGB1. NMR structures of two bent DNA oligomers, only one of which binds strongly to HMGB1, revealed that the presence of a pocket structure on the minor groove is crucial for strong binding through penetration of a phenylalanine residue.

PubMed: 21443191
DOI: 10.1021/ja2013399

実験手法

SOLUTION NMR