2RQR

The solution structure of human DOCK2 SH3 domain - ELMO1 peptide chimera complex

2RQR の概要

• エントリーDOI: 10.2210/pdb2rqr/pdb
• 分子名称: Engulfment and cell motility protein 1,Dedicator of cytokinesis protein 2 (1 entity in total)
• 機能のキーワード: kiaa0209, kiaa0281, apoptosis, membrane, phagocytosis, phosphoprotein, sh3-binding, cytoskeleton, guanine-nucleotide releasing factor, sh3 domain, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12635.98

構造登録者

Yokoyama, S.,Tochio, N.,Koshiba, S.,Kigawa, T.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2009-10-21, 公開日: 2010-10-27, 最終更新日: 2024-05-01)

• 主引用文献: Hanawa-Suetsugu, K.,Kukimoto-Niino, M.,Mishima-Tsumagari, C.,Akasaka, R.,Ohsawa, N.,Sekine, S.,Ito, T.,Tochio, N.,Koshiba, S.,Kigawa, T.,Terada, T.,Shirouzu, M.,Nishikimi, A.,Uruno, T.,Katakai, T.,Kinashi, T.,Kohda, D.,Fukui, Y.,Yokoyama, S.; Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.; Proc.Natl.Acad.Sci.USA, 109:3305-3310, 2012; PubMed: 22331897; DOI: 10.1073/pnas.1113512109

実験手法

SOLUTION NMR