2RMX

Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A

Summary for 2RMX

• Entry DOI: 10.2210/pdb2rmx/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 6, NKG2-A/NKG2-B type II integral membrane protein (2 entities in total)
• Functional Keywords: sh2 domain, protein-peptide complex, phosphorylated peptide recognition, phosphotyrosine binding domain, signal transduction, alternative splicing, cytoplasm, hydrolase, nucleus, phosphoprotein, protein phosphatase, glycoprotein, lectin, membrane, receptor, signal-anchor, transmembrane, signaling protein, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: P29350; Membrane; Single-pass type II membrane protein: P26715
• Total number of polymer chains: 2
• Total formula weight: 14364.83

Authors

Kasai, T.,Koshiba, S.,Inoue, M.,Kigawa, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-11-30, release date: 2008-12-02, Last modification date: 2022-03-16)

• Primary citation: Koshiba, S.,Kasai, T.,Sato, M.,Tomizawa, T.,Motoda, Y.,Tochio, N.,Kobayashi, N.,Harada, T.,Inoue, M.,Tanaka, A.,Kigawa, T.,Yokoyama, S.; Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1; To be Published,

Experimental method

SOLUTION NMR