2RKI
Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI
Summary for 2RKI
Entry DOI | 10.2210/pdb2rki/pdb |
Descriptor | HIV-1 reverse transcriptase (RT) p66, HIV-1 reverse transcriptase (RT) p51, 4-benzyl-3-[(2-chlorobenzyl)sulfanyl]-5-thiophen-2-yl-4H-1,2,4-triazole, ... (8 entities in total) |
Functional Keywords | hiv-1, reverse transcriptase, rt, non-nucleoside reverse transcriptase inhibitor, nnrti, rnase h, polymerase, virus, aids, aspartyl protease, capsid maturation, core protein, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, host-virus interaction, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphorylation, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc-finger |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 117133.92 |
Authors | Lansdon, E.B.,Kirschberg, T.A. (deposition date: 2007-10-16, release date: 2008-04-22, Last modification date: 2023-08-30) |
Primary citation | Kirschberg, T.A.,Balakrishnan, M.,Huang, W.,Hluhanich, R.,Kutty, N.,Liclican, A.C.,McColl, D.J.,Squires, N.H.,Lansdon, E.B. Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase-structure-activity relationships and crystallographic analysis. Bioorg.Med.Chem.Lett., 18:1131-1134, 2008 Cited by PubMed: 18083512DOI: 10.1016/j.bmcl.2007.11.127 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report