2RKI

Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI

2RKI の概要

• エントリーDOI: 10.2210/pdb2rki/pdb
• 分子名称: HIV-1 reverse transcriptase (RT) p66, HIV-1 reverse transcriptase (RT) p51, 4-benzyl-3-[(2-chlorobenzyl)sulfanyl]-5-thiophen-2-yl-4H-1,2,4-triazole, ... (8 entities in total)
• 機能のキーワード: hiv-1, reverse transcriptase, rt, non-nucleoside reverse transcriptase inhibitor, nnrti, rnase h, polymerase, virus, aids, aspartyl protease, capsid maturation, core protein, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, host-virus interaction, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphorylation, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc-finger
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117133.92

構造登録者

Lansdon, E.B.,Kirschberg, T.A. (登録日: 2007-10-16, 公開日: 2008-04-22, 最終更新日: 2023-08-30)

• 主引用文献: Kirschberg, T.A.,Balakrishnan, M.,Huang, W.,Hluhanich, R.,Kutty, N.,Liclican, A.C.,McColl, D.J.,Squires, N.H.,Lansdon, E.B.; Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase-structure-activity relationships and crystallographic analysis.; Bioorg.Med.Chem.Lett., 18:1131-1134, 2008; PubMed: 18083512; DOI: 10.1016/j.bmcl.2007.11.127

実験手法

X-RAY DIFFRACTION (2.3 Å)