2RG5

Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11B

2RG5 の概要

• エントリーDOI: 10.2210/pdb2rg5/pdb
• 分子名称: Mitogen-activated protein kinase 14, N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide (3 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, kinase, transferase, p38 map kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42487.42

構造登録者

Sack, J.S. (登録日: 2007-10-02, 公開日: 2008-01-15, 最終更新日: 2024-02-21)

• 主引用文献: Hynes, J.,Dyckman, A.J.,Lin, S.,Wrobleski, S.T.,Wu, H.,Gillooly, K.M.,Kanner, S.B.,Lonial, H.,Loo, D.,McIntyre, K.W.,Pitt, S.,Shen, D.R.,Shuster, D.J.,Yang, X.,Zhang, R.,Behnia, K.,Zhang, H.,Marathe, P.H.,Doweyko, A.M.,Tokarski, J.S.,Sack, J.S.,Pokross, M.,Kiefer, S.E.,Newitt, J.A.,Barrish, J.C.,Dodd, J.,Schieven, G.L.,Leftheris, K.; Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors; J.Med.Chem., 51:4-16, 2008; PubMed: 18072718; DOI: 10.1021/jm7009414

実験手法

X-RAY DIFFRACTION (2.4 Å)