2RFX

Crystal Structure of HLA-B*5701, presenting the self peptide, LSSPVTKSF

2RFX の概要

• エントリーDOI: 10.2210/pdb2rfx/pdb
• 関連するPDBエントリー: 2bvo 2bvp 2bvq 2hjk 2hjl
• 分子名称: HLA class I histocompatibility antigen, B-57 alpha chain, Beta-2-microglobulin, LSSPVTKSF, ... (5 entities in total)
• 機能のキーワード: alpha beta sandwich-immunologlobulin like, glycoprotein, host-virus interaction, immune response, membrane, mhc i, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P18465; Secreted . Note=(Microbial infection) In the presence of M: P61769
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44721.70

構造登録者

Archbold, J.K.,Macdonald, W.A.,Rossjohn, J.,McCluskey, J. (登録日: 2007-10-02, 公開日: 2008-07-08, 最終更新日: 2023-10-25)

• 主引用文献: Chessman, D.,Kostenko, L.,Lethborg, T.,Purcell, A.W.,Williamson, N.A.,Chen, Z.,Kjer-Nielsen, L.,Mifsud, N.A.,Tait, B.D.,Holdsworth, R.,Almeida, C.A.,Nolan, D.,Macdonald, W.A.,Archbold, J.K.,Kellerher, A.D.,Marriott, D.,Mallal, S.,Bharadwaj, M.,Rossjohn, J.,McCluskey, J.; Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity; Immunity, 28:822-832, 2008; PubMed: 18549801; DOI: 10.1016/j.immuni.2008.04.020

実験手法

X-RAY DIFFRACTION (2.5 Å)