2REA
Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.
Summary for 2REA
Entry DOI | 10.2210/pdb2rea/pdb |
Related | 2ar5 2RED |
Descriptor | Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (2 entities in total) |
Functional Keywords | px domain, pi3k, kinase, transferase, phosphorylation, nuclear protein, phosphoinositide, cytoplasm, cytoplasmic vesicle, golgi apparatus, membrane, nucleus, polymorphism |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane: O00443 |
Total number of polymer chains | 1 |
Total formula weight | 14375.57 |
Authors | Parkinson, G.N.,Vines, D.,Driscoll, P.C.,Djordjevic, S. (deposition date: 2007-09-26, release date: 2007-11-27, Last modification date: 2023-08-30) |
Primary citation | Parkinson, G.N.,Vines, D.,Driscoll, P.C.,Djordjevic, S. Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding Bmc Struct.Biol., 8:13-13, 2008 Cited by PubMed: 18312637DOI: 10.1186/1472-6807-8-13 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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