2RCX
AmpC Beta-lactamase in complex with (1R)-1-(2-Thiophen-2-yl-acetylamino)-1-(3-(2-carboxyvinyl)-phenyl) methylboronic acid
Summary for 2RCX
Entry DOI | 10.2210/pdb2rcx/pdb |
Related | 1FSW 1KE4 1MXO |
Descriptor | Beta-lactamase, (1R)-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-1-(3-(2-CARBOXYVINYL)-PHENYL) METHYLBORONIC ACID, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | ampc, beta-lactamase, cephalosporinase, serine hydrolase, antibiotic resistance, periplasm, hydrolase |
Biological source | Escherichia coli |
Cellular location | Periplasm: P00811 |
Total number of polymer chains | 2 |
Total formula weight | 80056.14 |
Authors | Morandi, F.,Morandi, S.,Prati, F.,Shoichet, B.K. (deposition date: 2007-09-20, release date: 2007-11-27, Last modification date: 2023-08-30) |
Primary citation | Morandi, S.,Morandi, F.,Caselli, E.,Shoichet, B.K.,Prati, F. Structure-based optimization of cephalothin-analogue boronic acids as beta-lactamase inhibitors Bioorg.Med.Chem., 16:1195-1205, 2008 Cited by PubMed: 17997318DOI: 10.1016/j.bmc.2007.10.075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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