2RCX

AmpC Beta-lactamase in complex with (1R)-1-(2-Thiophen-2-yl-acetylamino)-1-(3-(2-carboxyvinyl)-phenyl) methylboronic acid

Summary for 2RCX

• Entry DOI: 10.2210/pdb2rcx/pdb
• Related: 1FSW 1KE4 1MXO
• Descriptor: Beta-lactamase, (1R)-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-1-(3-(2-CARBOXYVINYL)-PHENYL) METHYLBORONIC ACID, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: ampc, beta-lactamase, cephalosporinase, serine hydrolase, antibiotic resistance, periplasm, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 80056.14

Authors

Morandi, F.,Morandi, S.,Prati, F.,Shoichet, B.K. (deposition date: 2007-09-20, release date: 2007-11-27, Last modification date: 2023-08-30)

• Primary citation: Morandi, S.,Morandi, F.,Caselli, E.,Shoichet, B.K.,Prati, F.; Structure-based optimization of cephalothin-analogue boronic acids as beta-lactamase inhibitors; Bioorg.Med.Chem., 16:1195-1205, 2008; PubMed: 17997318; DOI: 10.1016/j.bmc.2007.10.075

Experimental method

X-RAY DIFFRACTION (2 Å)