2RA4

Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)

2RA4 の概要

• エントリーDOI: 10.2210/pdb2ra4/pdb
• 分子名称: Small-inducible cytokine A13, SULFATE ION, trifluoroacetic acid, ... (4 entities in total)
• 機能のキーワード: ccl13, mcp-4, cc chemokine family, chemotaxis, monocytes, cytokine, inflammatory response, pyrrolidone carboxylic acid, secreted
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: Q99616
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 18185.19

構造登録者

Lubkowski, J.,Barinka, C. (登録日: 2007-09-14, 公開日: 2008-03-18, 最終更新日: 2024-10-30)

主引用文献

Barinka, C.,Prahl, A.,Lubkowski, J.
Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13).
Acta Crystallogr.,Sect.D, 64:273-278, 2008

PubMed Abstract: Monocyte chemoattractant proteins (MCPs) belong to the CC chemokine family and are involved in many (patho)physiological processes characterized by mononuclear cell infiltration, including tissue remodeling, atherosclerosis and cancer metastasis. Here, the crystal structure of human monocyte chemoattractant protein 4 (MCP-4) refined at 1.70 A resolution is reported with crystallographic values R = 0.180 and R free = 0.212. The overall MCP-4 fold reveals the typical tertiary features of the CC chemokine family. A central three-stranded antiparallel beta-sheet is C-terminally flanked by an overlaying alpha-helix, while the N-terminal part of the molecule forms an extended loop that is anchored to the rest of the molecule via two disulfide bridges, Cys11-Cys35 and Cys12-Cys51. The crystal packing suggests the existence of MCP-4 dimers with a dimerization interface similar to those previously reported for the X-ray structures of MCP-1 and MCP-2.

PubMed: 18323622
DOI: 10.1107/S0907444907066164

実験手法

X-RAY DIFFRACTION (1.7 Å)