2R59

Leukotriene A4 hydrolase complexed with inhibitor RB3041

2R59 の概要

• エントリーDOI: 10.2210/pdb2r59/pdb
• 関連するPDBエントリー: 1GW6 1H19 1HS6 1SQM
• 分子名称: Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (6 entities in total)
• 機能のキーワード: transition state, analogue peptide, hydrolysis, alternative splicing, cytoplasm, hydrolase, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, zinc
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 70854.67

構造登録者

Tholander, F.,Haeggstrom, J.Z.,Thunnissen, M.,Muroya, A.,Roques, B.P.,Fournie-Zaluski, M.C. (登録日: 2007-09-03, 公開日: 2008-08-12, 最終更新日: 2024-04-03)

• 主引用文献: Tholander, F.,Muroya, A.,Roques, B.P.,Fournie-Zaluski, M.C.,Thunnissen, M.M.,Haeggstrom, J.Z.; Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.; Chem.Biol., 15:920-929, 2008; PubMed: 18804029; DOI: 10.1016/j.chembiol.2008.07.018

実験手法

X-RAY DIFFRACTION (1.89 Å)