2R3J

Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor

2R3J の概要

関連するPDBエントリー2R3F 2R3G 2R3H 2R3I 2R3K 2R3L 2R3M 2R3N 2R3O 2R3P 2R3Q 2R3R
分子名称Cell division protein kinase 2, 3-bromo-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine (3 entities in total)
機能のキーワードserine/threonine-protein kinase, cell cycle, inhibition, cyclin-dependent kinase, cancer, atp-binding, cell division, mitosis, nucleotide-binding, phosphorylation, polymorphism, transferase
由来する生物種Homo sapiens (human)
ポリマー鎖数1
分子量合計34414.77
構造登録者
Fischmann, T.O.,Hruza, A.W.,Madison, V.M.,Duca, J.S. (登録日: 2007-08-29, 公開日: 2008-01-22, 最終更新日: 2011-07-13)
主引用文献
Fischmann, T.O.,Hruza, A.,Duca, J.S.,Ramanathan, L.,Mayhood, T.,Windsor, W.T.,Le, H.V.,Guzi, T.J.,Dwyer, M.P.,Paruch, K.,Doll, R.J.,Lees, E.,Parry, D.,Seghezzi, W.,Madison, V.
Structure-guided discovery of cyclin-dependent kinase inhibitors.
Biopolymers, 89:372-379, 2008
PubMed: 17937404 (主引用文献が同じPDBエントリー)
DOI: 10.1002/bip.20868
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.65 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2551905.7%13.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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