Summary for 2R2X
| Entry DOI | 10.2210/pdb2r2x/pdb |
| Related | 2P8N 2PJO 2R3D |
| Descriptor | Ricin A chain, SULFATE ION, UREA, ... (4 entities in total) |
| Functional Keywords | ricin, ricinus communis, n-glycosidase, toxin, glycoprotein, hydrolase, lectin, plant defense, protein synthesis inhibitor |
| Biological source | Ricinus communis (castor bean) |
| Total number of polymer chains | 1 |
| Total formula weight | 30320.13 |
| Authors | Carra, J.H.,McHugh, C.A.,Mulligan, S.,Machiesky, L.M.,Soares, A.S.,Millard, C.B. (deposition date: 2007-08-28, release date: 2007-11-20, Last modification date: 2024-02-21) |
| Primary citation | Carra, J.H.,McHugh, C.A.,Mulligan, S.,Machiesky, L.M.,Soares, A.S.,Millard, C.B. Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site. Bmc Struct.Biol., 7:72-72, 2007 Cited by PubMed Abstract: Ricin is a potent toxin and known bioterrorism threat with no available antidote. The ricin A-chain (RTA) acts enzymatically to cleave a specific adenine base from ribosomal RNA, thereby blocking translation. To understand better the relationship between ligand binding and RTA active site conformational change, we used a fragment-based approach to find a minimal set of bonding interactions able to induce rearrangements in critical side-chain positions. PubMed: 17986339DOI: 10.1186/1472-6807-7-72 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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