2R18

Structural insights into the multifunctional protein VP3 of Birnaviruses

2R18 の概要

• エントリーDOI: 10.2210/pdb2r18/pdb
• 関連するPDBエントリー: 2Z7J
• 分子名称: Capsid assembly protein VP3 (2 entities in total)
• 機能のキーワード: helix, capsid protein, hydrolase, protease, serine protease, virion, viral protein
• 由来する生物種: Infectious bursal disease virus (Gumboro virus)
• 細胞内の位置: Capsid protein VP2: Virion . Capsid protein VP3: Virion . Structural peptide 1: Virion . Structural peptide 2: Virion . Structural peptide 3: Virion . Structural peptide 4: Virion : P25220
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15791.62

構造登録者

Casanas, A.,Navarro, A.,Ferrer-Orta, C.,Gonzalez, D.,Rodriguez, J.F.,Verdaguer, N. (登録日: 2007-08-22, 公開日: 2008-02-05, 最終更新日: 2024-02-21)

主引用文献

Casanas, A.,Navarro, A.,Ferrer-Orta, C.,Gonzalez, D.,Rodriguez, J.F.,Verdaguer, N.
Structural insights into the multifunctional protein VP3 of birnaviruses.
Structure, 16:29-37, 2008

PubMed Abstract: Infectious bursal disease virus (IBDV), a member of the Birnaviridae family, is the causative agent of one of the most harmful poultry diseases. The IBDV genome encodes five mature proteins; of these, the multifunctional protein VP3 plays an essential role in virus morphogenesis. This protein, which interacts with the structural protein VP2, with the double-stranded RNA genome, and with the virus-encoded, RNA-dependent RNA polymerase, VP1, is involved not only in the formation of the viral capsid, but also in the recruitment of VP1 into the capsid and in the encapsidation of the viral genome. Here, we report the X-ray structure of the central region of VP3, residues 92-220, consisting of two alpha-helical domains connected by a long and flexible hinge that are organized as a dimer. Unexpectedly, the overall fold of the second VP3 domain shows significant structural similarities with different transcription regulation factors.

PubMed: 18184581
DOI: 10.1016/j.str.2007.10.023

実験手法

X-RAY DIFFRACTION (2.3 Å)