2QYP

Orthorhombic Crystal Structure of Human Saposin C Dimer in Open Conformation

2QYP の概要

• エントリーDOI: 10.2210/pdb2qyp/pdb
• 分子名称: Proactivator polypeptide (1 entity in total)
• 機能のキーワード: saposin, activator protein, sap, alternative splicing, disease mutation, gaucher disease, glycoprotein, gm2-gangliosidosis, lipid metabolism, lysosome, metachromatic leukodystrophy, sphingolipid metabolism, lipid binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P07602
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20757.72

構造登録者

Rossmann, M.,Saenger, W.,Maier, T. (登録日: 2007-08-15, 公開日: 2008-04-29, 最終更新日: 2011-07-13)

• 主引用文献: Rossmann, M.,Schultz-Heienbrok, R.,Behlke, J.,Remmel, N.,Alings, C.,Sandhoff, K.,Saenger, W.,Maier, T.; Crystal structures of human saposins C and d: implications for lipid recognition and membrane interactions.; Structure, 16:809-817, 2008; PubMed: 18462685; DOI: 10.1016/j.str.2008.02.016

実験手法

X-RAY DIFFRACTION (2.45 Å)