2QWK

THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE

2QWK の概要

• エントリーDOI: 10.2210/pdb2qwk/pdb
• 分子名称: NEURAMINIDASE, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: neuraminidase, influenza protein, sialic acid analogues, dana anologues, gs4071. neuraminidase, drug resistant variant, glycosylated protein, hydrolase, gs4071
• 由来する生物種: Influenza A virus
• 細胞内の位置: Virion membrane (By similarity): P03472
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45968.99

構造登録者

Varghese, J.N. (登録日: 1998-04-07, 公開日: 1998-11-11, 最終更新日: 2024-04-03)

• 主引用文献: Varghese, J.N.,Smith, P.W.,Sollis, S.L.,Blick, T.J.,Sahasrabudhe, A.,McKimm-Breschkin, J.L.,Colman, P.M.; Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.; Structure, 6:735-746, 1998; PubMed: 9655825; DOI: 10.1016/S0969-2126(98)00075-6

実験手法

X-RAY DIFFRACTION (1.8 Å)