2QVS

Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase

Summary for 2QVS

• Entry DOI: 10.2210/pdb2qvs/pdb
• Related: 1cx4 1rgs 1u7e
• Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase type II-alpha regulatory subunit (3 entities in total)
• Functional Keywords: camp-dependent protein kinase, type iia holoenzyme, isoform diversity, alternative splicing, atp-binding, cytoplasm, lipoprotein, myristate, nucleotide-binding, nucleus, phosphorylation, serine/threonine-protein kinase, transferase, acetylation, camp-binding, transferase-transferase regulator complex, transferase/transferase regulator
• Biological source: Mus musculus (house mouse); More
• Cellular location: Cytoplasm (By similarity): P05132
• Total number of polymer chains: 2
• Total formula weight: 75958.33

Authors

Wu, J.,Brown, S.H.J.,von Daake, S.,Taylor, S.S. (deposition date: 2007-08-08, release date: 2007-10-23, Last modification date: 2023-08-30)

• Primary citation: Wu, J.,Brown, S.H.J.,von Daake, S.,Taylor, S.S.; PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.; Science, 318:274-279, 2007; PubMed: 17932298; DOI: 10.1126/science.1146447

Experimental method

X-RAY DIFFRACTION (2.5 Å)