2QVS

Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase

2QVS の概要

• エントリーDOI: 10.2210/pdb2qvs/pdb
• 関連するPDBエントリー: 1cx4 1rgs 1u7e
• 分子名称: cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase type II-alpha regulatory subunit (3 entities in total)
• 機能のキーワード: camp-dependent protein kinase, type iia holoenzyme, isoform diversity, alternative splicing, atp-binding, cytoplasm, lipoprotein, myristate, nucleotide-binding, nucleus, phosphorylation, serine/threonine-protein kinase, transferase, acetylation, camp-binding, transferase-transferase regulator complex, transferase/transferase regulator
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Cytoplasm (By similarity): P05132
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75958.33

構造登録者

Wu, J.,Brown, S.H.J.,von Daake, S.,Taylor, S.S. (登録日: 2007-08-08, 公開日: 2007-10-23, 最終更新日: 2023-08-30)

• 主引用文献: Wu, J.,Brown, S.H.J.,von Daake, S.,Taylor, S.S.; PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.; Science, 318:274-279, 2007; PubMed: 17932298; DOI: 10.1126/science.1146447

実験手法

X-RAY DIFFRACTION (2.5 Å)