2QVE

Crystal Structure of SgTAM bound to mechanism based inhibitor

Summary for 2QVE

• Entry DOI: 10.2210/pdb2qve/pdb
• Related: 2OHY
• Descriptor: Tyrosine Aminomutase, (3R)-3-amino-2,2-difluoro-3-(4-hydroxyphenyl)propanoic acid (3 entities in total)
• Functional Keywords: mio, aminomutase, enediyne, transferase
• Biological source: Streptomyces globisporus
• Total number of polymer chains: 2
• Total formula weight: 114341.02

Authors

Christianson, C.V.,Montavon, T.J.,Bruner, S.D. (deposition date: 2007-08-08, release date: 2008-07-22, Last modification date: 2023-11-15)

Primary citation

Montavon, T.J.,Christianson, C.V.,Festin, G.M.,Shen, B.,Bruner, S.D.
Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM
Bioorg.Med.Chem.Lett., 18:3099-3102, 2008

PubMed Abstract: The synthesis and evaluation of two classes of inhibitors for SgTAM, a 4-methylideneimidazole-5-one (MIO) containing tyrosine aminomutase, are described. A mechanism-based strategy was used to design analogs that mimic the substrate or product of the reaction and form covalent interactions with the enzyme through the MIO prosthetic group. The analogs were characterized by measuring inhibition constants and X-ray crystallographic structural analysis of the co-complexes bound to the aminomutase, SgTAM.

PubMed: 18078753
DOI: 10.1016/j.bmcl.2007.11.046

Experimental method

X-RAY DIFFRACTION (2 Å)