2QUG
Crystal structure of alpha-1-antitrypsin, crystal form A
Summary for 2QUG
Entry DOI | 10.2210/pdb2qug/pdb |
Descriptor | Alpha-1-antitrypsin (2 entities in total) |
Functional Keywords | antitrypsin, polymerisation, protein aggregation, protein unfolding, serpin, acute phase, disease mutation, glycoprotein, protease inhibitor, secreted, serine protease inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009 |
Total number of polymer chains | 1 |
Total formula weight | 44410.36 |
Authors | Hansen, G.,Morton, C.J.,Pearce, M.C.,Feil, S.C.,Adams, J.J.,Parker, M.W.,Bottomley, S.P. (deposition date: 2007-08-05, release date: 2008-08-12, Last modification date: 2011-07-13) |
Primary citation | Pearce, M.C.,Morton, C.J.,Feil, S.C.,Hansen, G.,Adams, J.J.,Parker, M.W.,Bottomley, S.P. Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding. Protein Sci., 17:2127-2133, 2008 Cited by PubMed: 18780818DOI: 10.1110/ps.037234.108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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