2QTB

Human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl cyclohexylalanine inhibitor

2QTB の概要

• エントリーDOI: 10.2210/pdb2qtb/pdb
• 関連するPDBエントリー: 2QT9
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: alpha/beta, beta-propeller, dimer, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 182829.49

構造登録者

Scapin, G. (登録日: 2007-08-01, 公開日: 2007-11-06, 最終更新日: 2023-08-30)

• 主引用文献: Kaelin, D.E.,Smenton, A.L.,Eiermann, G.J.,He, H.,Leiting, B.,Lyons, K.A.,Patel, R.A.,Patel, S.B.,Petrov, A.,Scapin, G.,Wu, J.K.,Thornberry, N.A.,Weber, A.E.,Duffy, J.L.; 4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.; Bioorg.Med.Chem.Lett., 17:5806-5811, 2007; PubMed: 17851076; DOI: 10.1016/j.bmcl.2007.08.049

実験手法

X-RAY DIFFRACTION (2.25 Å)